Abstract
Objectives
This study aims to evaluate the efficacy, safety, and application of platelet-poor plasma gel (PPP gel) as an autologous dermal filler for esthetic enhancements and facial rejuvenation. The primary objective is to assess the subjective esthetic improvement using the global esthetic improvement (GAI) scale and to evaluate the safety profile. The secondary objective is to evaluate the patients’ satisfaction scores to highlight both the psychological and esthetic benefits.
Materials and Methods
Thirty patients, who presented with various facial concerns such as tear trough deformity, facial aging, facial asymmetry, scars like acne scars, post-burn scar and post-varicella scar, and facial rejuvenation, who attended the dermatology and venereology outpatient department at our tertiary care hospital received the treatment after taking a written and informed consent. Each treatment involved a thorough patient evaluation, preparation of the PPP gel from the patient’s own blood, and precise injections according to their individual requirements. They were assessed clinically before treatment sessions and at the end of the follow-up period of two months. Statistical analysis was performed to confirm the significance of this study.
Results
Most of the patients had a significant clinical improvement immediately post-procedure that was maintained until the end of the follow-up period in 53.3% of the patients. This finding was confirmed by the statistically significant difference in the GAI scores of pre- and post-treatment and P < 0.05, proving that autologous PPP gel is efficacious. Mild erythema, pain, and burning sensation were noted immediately post-procedure but these were short lived. None of the patients had any other side effects or serious complications during the follow-up period. The overall satisfaction score (using a Likert scale) of 3.52 indicates a high level of patient contentment with the PPP gel procedure, reflecting positive experiences and outcomes.
Conclusion
This article introduces a novel aspect of esthetic dermatology, highlighting the potential of autologous PPP gel as an innovative, biocompatible, and cost-effective alternative to synthetic biofillers. By promoting collagen synthesis and skin rejuvenation while minimizing hypersensitivity risks, PPP gel presents a promising advancement in regenerative esthetics. However, its temporary volumizing nature and lack of immediate reversibility, if injector-induced complications are encountered, necessitate further clinical exploration. Future research on long-term efficacy and safety, comparative trials, and hybrid formulations may refine the standardization of preparation and properties of PPP gel. As esthetic medicine advances, integrating PPP gel biofillers could enhance cost-effectiveness, personalization, and treatment outcomes.
Read the full article here https://cosmoderma.org/the-efficacy-safety-and-application-of-platelet-poor-plasma-gel-as-an-autologous-dermal-filler-for-esthetic-enhancements-and-facial-rejuvenation-a-pilot-study/ or via www.avaderm.academy
